THE ADAPTATION RATE OF ASEXUALS: DELETERIOUS MUTATIONS, CLONAL INTERFERENCE AND POPULATION BOTTLENECKS
نویسندگان
چکیده
منابع مشابه
Hypermutability in Asexuals: Investigating the Effects of Deleterious Mutations
Mutation is the ultimate source of the genetic variation—including genetic variation for mutation rate itself—that fuels evolution. Selection to increase the genomic mutation rate, driven by selective sweeps of beneficial mutations, can be strong and rapid where genetic linkage is present, as evidenced by numerous observations in experimental microbial populations. Selection to decrease the mut...
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Fisher and Muller's theory that recombination speeds adaptation by eliminating competition among beneficial mutations has proved a popular explanation for the advantage of sex. Recent theoretical studies have attempted to quantify the speed of adaptation under the Fisher-Muller model, partly in an attempt to understand the role of "clonal interference" in microbial experimental evolution. We re...
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I study the population genetics of adaptation in asexuals. I show that the rate of adaptive substitution in an asexual species or nonrecombining chromosome region is a bell-shaped function of the mutation rate: at some point, increasing the mutation rate decreases the rate of substitution. Curiously, the mutation rate that maximizes the rate of adaptation depends solely on the strength of selec...
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Two important problems affect the ability of asexual populations to accumulate beneficial mutations and hence to adapt. First, clonal interference causes some beneficial mutations to be outcompeted by more-fit mutations that occur in the same genetic background. Second, multiple mutations occur in some individuals, so even mutations of large effect can be outcompeted unless they occur in a good...
متن کاملThe Influence of Deleterious Mutations on Adaptation in Asexual Populations
We study the dynamics of adaptation in asexual populations that undergo both beneficial and deleterious mutations. In particular, how the deleterious mutations affect the fixation of beneficial mutations was investigated. Using extensive Monte Carlo simulations, we find that in the "strong-selection weak mutation (SSWM)" regime or in the "clonal interference (CI)" regime, deleterious mutations ...
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ژورنال
عنوان ژورنال: Evolution
سال: 2010
ISSN: 0014-3820,1558-5646
DOI: 10.1111/j.1558-5646.2010.00981.x